In addition to editing over twenty LGBTQIA+ anthologies, Radclyffe has written over seventy romance and romantic intrigue novels, including a paranormal romance series, The Midnight Hunters, as L.L. Raand.
She is a three-time Lambda Literary Award winner in romance and erotica and received the Dr. James Duggins Outstanding Mid-Career Novelist Award from the Lambda Literary Foundation. A member of the Saints and Sinners Literary Hall of Fame, she is also an RWA / FF&P Prism Award winner for Secrets in the Stone, an RWA FTHRW Lories and RWA HODRW winner for Firestorm, an RWA Bean Pot winner for Crossroads, an RWA Laurel Wreath winner for Blood Hunt, a Book Buyers Best award winner for Price of Honor and Secret Hearts, and a 2023 Golden Crown Literary Award winner for Perfect Rivalry. The first book in the Red Sky Ranch romance series, co-written with Julie Cannon, Fire in the Sky, was a 2024 GCLS romance award winner. She is also a featured author in the 2015 documentary film Love Between the Covers, from Blueberry Hill Productions. In 2019, she was recognized as a Trailblazer of Romance by the Romance Writers of America. She was named a Woman of the Year by The Advocate (2021), included in the Out100 (2022), and is a member of Curve's Power List (2025).
In 2004 she founded Bold Strokes Books, one of the world’s largest independent LGBTQ publishing companies, and is the current president and publisher.